John M. Stafford

Assistant Professor
Department of Medicine
Division of Diabetes, Endocrinology, & Metabolism
and Molecular Physiology and Biophysics
Vanderbilt University Medical Center
7445 MRB4
Nashville, TN 37232-0475


1. Scott, D.K., R.M. O-Doherty, J.M. Stafford, C.B. Newgard, and D.K. Granner. 1998. The repression of hormone-activated PEPCK gene expression by glucose is insulin independent but requires glucose metabolism. J Biol Chem. 273:24145-24151. PMID: 9727036.

2. Wang, J.C.*, J.M. Stafford*, and D.K. Granner. 1998. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem. 273:30847- 0850. PMID:9812974

3. Pierreux, C.E., J.M. Stafford, D. Demonte, D.K. Scott, J. Vandenhaute, R.M. O-Brien, D.K. Granner, G.G. Rousseau, and F.P. Lemaigre. 1999. Antiglucocorticoid activity of hepatocyte nuclear factor-6. Proc Natl Acad Sci USA. 96:8961-8966. PMID:10430878. PMCID: PMC17715.

4. Wang, J.C., J.M. Stafford, D.K. Scott, C. Sutherland, and D.K. Granner. 2000. The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis. J Biol Chem. 275:14717-14721. PMID: 10799560.

5. Stafford, J.M., M. Waltner-Law, D.K. Granner. 2001. Role of Accessory Factors and SRC1 in the regulation of PEPCK gene transcription by glucocorticoids. J Biol Chem. 276:3811-3819. PMID: 11069927.

6. Yoon, J.C., P. Puigserver, G. Chen, J. Donovan, Z. Wu, J. Rhee, G. Adelmant, J.M. Stafford, C. R. Kahn, D.K. Granner, C.B. Newgard, B.M. Spiegelman. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413: 131-138. PMID:11557972.

7. Stafford, J.M., J. Wilkinson, J. Beechem, D.K. Granner. 2001. Accessory Factors Facilitate the Binding of Glucocorticoid Receptor to the PEPCK Gene Promoter. J Biol Chem. J. Biol. 276: 39885-39891. PMID: 11518712.

8. Stafford, J. M. 2001. Role of Accessory Factors in the Regulation of Phosphoenolpyruvate Carboxykinase Gene Transcription by Glucocorticoids. Dissertation. ISBN: 0-493-14472-2.

9. Stafford, J.M, F. Yu, R. Printz, A. Hasty, L. Swift, and K.D. Niswender. 2008. CNS neuropeptide Y signaling modulates VLDL triglyceride production. Diabetes. 57:1-9. PMID: 18332095.

10. Wu, K., D. Cappel, M. Martinez, and J.M. Stafford. 2010. Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum VLDL. Endocrinology. 115 (8): 3566-3576. PMID: 20501667. PMCID: PMC294051.

11. M.N. Martinez, C.H. Emfinger, M. Overton, S. Hill, T.S. Ramaswamy, D.A. Cappel, K. Wu, S. Fazio, D. Hachey, D.L. Tabb, J.M. Stafford. 2012. Obesity and altered carbohydrate metabolism impact HDL composition in CETP transgenic mice: A role for ovarian hormones. Journal of Lipid Research. Mar; 53 (3): 379-89. PMID: 22215797.

12. Zhu, L., W.C. Brown, Q. Cai, P. Chambon, O.P. McGuinness, J.M. Stafford. 2013. Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance. Diabetes. 62: 424-434. PMID: 22966069.

13. P. Luo, A. DeMatteo, Z. Wang, A. Wang, H-S Kim, A. Pozzi, J.M. Stafford, J.M. Luther, 2012. Aldosterone Deficiency Prevents High Fat Feeding-induced Hyperglycemia and Adipocyte Dysfunction in Mice. Diabetologia. 56 (4): p901-910. PMID: 23314847. PMCID: PMC3593801.

14. J.M. Rojas, J.M Stafford, R.L. Printz, S. Saadat, M.K. Turney, A. Beck-Sickinger, K.D. Niswender. 2012. Central Nervous System Neuropeptide Y signaling via the Y1 receptor partially uncouples feeding behavior from lipoprotein metabolism in lean rats.Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1479-88. PubMed PMID: 23074243; PubMed Central PMCID: PMC3532466.

15. D.A. Cappel, B.T. Palmisano C.H. Emfinger, M. Martinez, O.P McGuinness, J.M. Stafford. 2013. Cholesteryl Ester Transfer Protein Augments Insulin Sensitivity in Females with Obesity. Molecular Metabolism. 2: 457-467. PMID: 24327961. PMCID: PMC3854988

16. L. Zhu, C.H. Emfinger, B.T. Palmisano, J.M. Stafford. 2014. Estrogen signaling prevents diet-induced hepatic insulin resistance in males with obesity. Accepted, in press. American Journal of Physiology, Endocrinology and Metabolism.

17. Y. Otero, J.M.Stafford, O.P Mc Guinness. 2014. Pathway-Selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux. Journal of Biological Chemistry. 289 (30), 20462-20469

18. D.A Cappel, B.P Palmisano, L. Lantier, D. Wasserman, J.M. Stafford. 2015. Cholesteryl Ester Transfer Protein augments exercise capacity with obesity in female mice. PLoS One 10(8):e0136915

19. C. Dai, N.S. Kayton, A. Shostak, G. Poffenberger, H.A. Cyphert, R. Aramandla, C. Thompson, I.G. Papagiannis, C. Emfinger, M. Shiota, J.M. Stafford, D. Greiner, P.L. Herrera, L.D. Shultz, R. Stein, A.C. Powers. 2016. Stress-Impaired Transcription Factor Expression and Insulin Secretion in Human Islets. Journal of Clinical Investigation. April 11. PMID: 27064285

20. L. Zhu, I. Giunzioni, R. Covarrubias, L. Ding, Y. Zhang, H. Tavori, Amy S. Major, J.M. Stafford, M.F. Linton, and S. Fazio. 2016. Loss of Macrophage LDL Receptor Related Protein 1 (LRP1) Confers Resistance to the Anti-atherogenic Effects of Tumor Necrosis Factor α Inhibition. Arteriosclerosis, Thrombosis, and Vascular Biology 36 (8), 1483-1495

21. B.T. Palmisano, J.M. Stafford, J.S Pendergast. 2017. Ovarian Hormones Protect Daily Rhythms in Female Mice from High-Fat Diet. Frontiers in Endocrinology. 14 March 2017

22. B.T. Palmisano, T.D Le, L. Zhu, Y.K Lee, J.M. Stafford. 2016. Cholesteryl Ester Transfer Protein Alters Liver and Plasma Triglyceride Metabolism Through Two Distinct Liver Networks in Female Transgenic Mice.  Journal of Lipid Research. 57. 1541-1551. PMID: 27354419

23. L. Zhu, J. Shi, T. Luu, J. Neuman, E.Trefts, D. Wasserman, M.F. Linton, J.M. Stafford. 2017. Absence of liver estrogen alpha signaling predisposes mice to atherosclerosis during western-type diet feeding. Accepted, in Press Molecular Metabolism.

24. B.T. Palmisano, L.Zhu, J.M. Stafford. 2017. Role of Estrogens in the Regulation of Liver Lipid Metabolism. Adv Exp Med Biol. 2017;1043:227-256.  PMID: 29224098