Autonomic disorders cause loss of regulation of the heart, blood vessels, stomach, bowel and bladder. Affected patients may have palpitations or lose consciousness, and some have a rapidly fatal course. We hope to join with patient support groups to harness the knowledge and energies of physicians and investigators in the major centers where these patients are cared for, so that they can discover ways to treat and to cure these diseases. The greater the collaboration between doctors and patients, the more we can learn about these disorders. This important first step is necessary if we are ever to find genuinely effective and curative treatments.