What are the Uncertainties about POTS?

We need to understand more about where normal ends and where OI begins. We need to know the interrelationships of OI and deconditioning. Both OI and deconditioning share many clinical features and their separation can prove challenging. Perhaps more challenging is the fact that many patients with OI respond to their illness by reducing their physical activity. When they present to physicians, they therefore present with both OI and deconditioning.

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