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The focus of the Harrison lab is the role of vitamin C and its transporters (SVCT1 & SVCT2) in brain function during development and in neurodegenerative diseases.

The emphasis in the lab is the comorbid factors and disease states that drive Alzheimer's disease, particularly in its early stages. These areas offer potential to intervene in disease pathogenic pathways and delay or prevent disease development and cognitive decline.

We study the multifactorial roles of vitamin C in oxidative stress, gene expression, mitochondrial function and seizures.

We also study how obesity and diet-induced diabetic state impacts neuroinflammation and cognitive decline, and the extent to which these processes may be reversible.

Funding Sources

We are grateful to the following sources for funding:

The Division of Diabetes, Endocrinology & Metabolism, VUMC

The Vanderbilt/NIMH Silvio O. Conte Center for Neuroscience Research

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