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Rockann Mosser

Hometown:
Corpus Christi, TX

Education: 
Ph.D. in Biochemistry and Biophysics from Texas A&M University.
B.S. in Biochemistry from University of Texas at Austin

Research Topic:

Beta cell mass expands during times of metabolic need, such as during pregnancy and obesity.  Failure of beta cell mass expansion in response to metabolic demands can result in diabetes.  Therefore, understanding the mechanisms whereby proliferative signals impact beta cells is a crucial area of diabetes research.  One important tissue factor necessary for proliferation in post-natal beta cells is the FoxM1 transcription factor.

Our lab has previously shown that murine FoxM1 is needed for beta cell proliferation during pregnancy and after partial pancreatectomy; however, we do not know the role of FoxM1 in beta cell proliferation that occurs as a result of obesity.  One aspect of my project is to determine if FoxM1 has a role in beta cell expansion in mice in response to a high fat diet.  In order to address this question, I am using mice in which FoxM1 can be conditionally deleted from the beta cells and exposing them to high fat diet.    In addition, I am interested in understanding how FoxM1 is transcriptionally regulated by proliferative stimuli in beta cells.  I am using cultured beta cell lines and isolated islets to determine which secondary messenger pathways are utilized to regulate the transcription of FoxM1 and its activity in response to proliferative stimuli.  

 

Publications:

Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase.

Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD.

Biochemistry. 2013 Jul 16.

 

Structure of the apo form of Bacillus stearothermophilus phosphofructokinase.

Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD.

Biochemistry. 2012 Jan 24;51(3):769-75. doi: 10.1021/bi201548p. Epub 2012 Jan 11.