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Bethany Carboneau

maureen gannon lab

Hometown: Goshen, Indiana

Education: B.A. in Biology from Hanover College

Prostaglandins are important modulators of an array of physiologic functions including insulin secretion and systemic inflammation. EP3 and EP4 play opposing roles in many cell types due to signaling through different G proteins, resulting in Gi inhibition (EP3) or Gs stimulation (EP4) of adenylyl cyclase. We hypothesize that EP3 and EP4 play opposing roles in regulating β-cell mass expansion. Signaling via EP3 is predicted to inhibit β-cell proliferation whereas activation of EP4 is predicted to enhance β-cell proliferation and survival. I am using genetic and pharmacological tools to examine the effects of EP3 and EP4 signaling in β-cell proliferation and survival in vivo and in ex vivo studies using rodent and human islets.

Publications

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.

Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT.

Sci Rep. 2016 Jun 21;6:28159. doi: 10.1038/srep28159.

PMID: 27324831

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.

Thomas LR, Foshage AM, Weissmiller AM, Popay TM, Grieb BC, Qualls SJ, Ng V, Carboneau B, Lorey S, Eischen CM, Tansey WP.

Oncogene. 2015 Nov 2. doi: 10.1038/onc.2015.416. [Epub ahead of print]

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM.

Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20.

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.

Mosser RE, Maulis MF, Moull VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E573-82. doi: 10.1152/ajpendo.00460.2014. Epub 2015 Jan 27.

Of mice and men: the benefits of caloric restriction, exercise, and mimetics.

Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R.

Ageing Res Rev. 2012 Jul;11(3):390-8. doi: 10.1016/j.arr.2011.11.005. Epub 2011 Dec 20. Review.

Rotation at University of Alberta

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