Maureen Gannon, Ph.D.

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism

Department of Molecular Physiology and Biophysics

Department of Cell and Developmental Biology

Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232

office: (615) 936-2676
lab: (615) 936-2683
fax: (615) 936-1667

Gannon Lab Graduate Students

Bethany Carboneau

maureen gannon lab

Hometown: Goshen, Indiana

Education: B.A. in Biology from Hanover College

Prostaglandins are important modulators of an array of physiologic functions including insulin secretion and systemic inflammation. EP3 and EP4 play opposing roles in many cell types due to signaling through different G proteins, resulting in Gi inhibition (EP3) or Gs stimulation (EP4) of adenylyl cyclase. We hypothesize that EP3 and EP4 play opposing roles in regulating β-cell mass expansion. Signaling via EP3 is predicted to inhibit β-cell proliferation whereas activation of EP4 is predicted to enhance β-cell proliferation and survival. I am using genetic and pharmacological tools to examine the effects of EP3 and EP4 signaling in β-cell proliferation and survival in vivo and in ex vivo studies using rodent and human islets.

Peter Kropp

Hometown: Franklin, TN

maureen gannon lab

Education: BA in Molecular Biology from Colgate University

Research Topic:

I am interested in understanding the role of the transcription factor Oc1 (Onecut1) in pancreas development and disease. Oc1 is essential for development of the endocrine pancreas, so I am investigating its interaction its cofactor Pdx1 in that role. I have thus far determined that proper dosage of both Oc1 and Pdx1 is necessary for endocrine cell differentiation and that defects established during development persist into adulthood. I am also interested in the role of Oc1 in development of the exocrine pancreas, especially the digestive-enzyme secreting acinar cells. To that end, I am working to identify the targets of Oc1 during pancreas development through both ChIP-Seq and RNA-Seq. I am further determining the role of Oc1 in acinar cell development by inactivating Oc1 specifically in differentiated acinar cells. These studies will shed light on how developmental defects due to Oc1 misexpression could lead to adult diseases such as diabetes, pancreatitis, and pancreatic cancer.

Joey Elsakr

maureen gannon lab

Hometown: Daytona Beach, FL

Education: BS from Duke University

Research Topic: Non-human primates and high-fat diets, gestational diabetes.

Interests: Running. And getting two degrees at once (MD PhD)