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Recent Publications

Sex differences underlying pancreatic islet biology and its dysfunction.

Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F.

Mol Metab. 2018 Sep;15:82-91. doi: 10.1016/j.molmet.2018.05.017. Epub 2018 May 30. Review.


Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.

Carboneau BA, Breyer RM, Gannon M.

J Cell Commun Signal. 2017 Jun;11(2):105-116. doi: 10.1007/s12079-017-0377-7. Epub 2017 Jan 28. Review.

Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation.

Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M.

Mol Metab. 2017 Apr 5;6(6):548-559. doi: 10.1016/j.molmet.2017.04.002. eCollection 2017 Jun.

Unexpected effects of the MIP-CreER transgene and tamoxifen on β-cell growth in C57Bl6/J male mice.

Carboneau BA, Le TD, Dunn JC, Gannon M.

Physiol Rep. 2016 Sep;4(18). pii: e12863.

 Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury.

Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M.

Mol Metab. 2015 May 19;4(8):584-91. doi: 10.1016/j.molmet.2015.05.002. eCollection 2015 Aug.

Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.

Henley KD, Stanescu DE, Kropp PA, Wright CV, Won KJ, Stoffers DA, Gannon M.

Cell Rep. 2016 Jun 21;15(12):2637-50. doi: 10.1016/j.celrep.2016.05.040. Epub 2016 Jun 9.

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM.

Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20.

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.

Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M.

Diabetes. 2015 Nov;64(11):3829-38. doi: 10.2337/db15-0465. Epub 2015 Aug 6.

Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.

Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I.

J Biol Chem. 2015 Mar 20;290(12):7647-57. doi: 10.1074/jbc.M114.595579. Epub 2015 Feb 2.

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.

Mosser RE, Maulis MF, Moull VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E573-82. doi: 10.1152/ajpendo.00460.2014. Epub 2015 Jan 27.

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M.

Diabetes. 2015 Apr;64(4):1284-98. doi: 10.2337/db14-1195. Epub 2014 Nov 12.

Activated FoxM1 attenuates streptozotocin-mediated β-cell death.

Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA.

Mol Endocrinol. 2014 Sep;28(9):1435-47. doi: 10.1210/me.2014-1024. Epub 2014 Jul 29.

Loss of HNF6 expression correlates with human pancreatic cancer progression.

Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA.

Lab Invest. 2014 May;94(5):517-27. doi: 10.1038/labinvest.2014.47. Epub 2014 Mar 17.

An assay for small scale screening of candidate β cell proliferative factors using intact islets.

Mosser RE, Gannon M.

Biotechniques. 2013 Dec;55(6):310-2. doi: 10.2144/000114115.

Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling.

Mundy C, Gannon M, Popoff SN.

J Cell Physiol. 2014 May;229(5):672-81. doi: 10.1002/jcp.24491.

Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.

Pasek RC, Gannon M.

Am J Physiol Endocrinol Metab. 2013 Dec 1;305(11):E1327-38. doi: 10.1152/ajpendo.00425.2013. Epub 2013 Oct 1.

Peer reviewed articles

Wu F, Li R, Umino Y, Kaczynski TJ, Sapkota D, Li S, Xiang M, Fliesler SJ, Sherry DM, Gannon M, Solessio E, Mu X. Onecut1 is essential for horizontal cell genesis and retinal integrety. J Neurosci. 2013 Aug 7

Pasek RC, Gannon M. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2013 Oct 1. PMID 24085033. 

Henley KDGooding KAEconomides ANGannon MInactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab. 303(6):E752-61, 2012

 Uma Gunasekaran, Courtney W. Hudgens, Brian T. Wright, Matthew F. Maulis, and Maureen Gannon. Differential regulation of embryonic and adult beta cells. Cell Cycle, 11(13), pp2431-2442, 2012 

Guney M, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M. Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells. PNAS, 108(37), pp15242-15247, 2011 

 Moore MC, Menon R, Coate KC, Gannon M, Smith MS, Farmer B, Williams PE. Diet-induced impaired glucose tolerance and gestational diabetes in the dog. Journal of Applied Physiology, 110:458-467, 2011

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ. Conditional gene targeting in mouse pancreatic β-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59(12), pp3090-8, 2010

Vellanki R, Zhang L, Guney MA, Rocheleau J, Gannon M, Volchuk A. OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells. Endocrinology 151(9), pp4146-4157, 2010

Zhang*, H, Zhang*, J, Pope, CF, Crawford, LA, Vasavada, RC, Jagasia, SM, Gannon, M. Gestational diabetes resulting from impaired β-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen.  Diabetes. 2009

Zhang*, H, Tweedie, EA, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M.  Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mechanisms of Development. 2009.

Crawford, LA, Guney, MA, Oh, YA, Deyound, RA, Valenzuela, DM, Murphey, AJ, Yancopoulos, GD, Lyons, KM, Bringstock, DR, Economides, A, Gannon, M.  Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endo, 23(3), 324-36, 2009

Elghazi, L, Weiss, AJ, Barker, DJ, Callaghan, J, Staloch, L, Sandgren, EP, Gannon, M, Adsay, VN, Bernal-Mizrachi, E.  Regulation of pancreas plasticity and malignant transformation by Akt signaling.  Gastroenterology, 136(3), 1091-103, 2009

Ackermann Misfeldt, A, Costa, RH, Gannon, M. Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes, 57(11):3069-77, 2008

Wilding, CL, Tweedie Ables, E, Oh, YA, Boone, B, Levy, S, Gannon, M. Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One, 3(2), e1611, 2008

Gannon, M, Ables, ET, Crawford, L, Lowe, D, Offield, MF, Magnuson, MA, Wright, CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314(2), 406-17, 2008

Ackermann, AM, Gannon, M.  Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J. Mol Endo, 38(1-2), 193-206, 2007

Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007

Wiebe, PO, Korminsh, JD, Roper, VT, Fujitani, Y, Alston, NI, Zaret, KS, Wright, CV, Stein, RW, Gannon, M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 Expression. Mol Cell Biol, 27(11), 4093-204, 2007

Boyer, DF, Fujitani, Y, Gannon, M, Powers, AC, Stein, RW, Wright, CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol, 298(2), 616-31, 2006

Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006

Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006

Tweedie, E, Artner, I, Crawford, L, Poffenberger, G, Thorens, B, Stein, R, Powers, AC, Gannon, M.  Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta cells.  Diabetes, 55(12), 3264-70, 2006

Zhang, H, Ackermann, AM, Gusarova, GA, Lowe, D, Feng, X, Kopsombut, UG, Costa, RH, Gannon, M. The Foxm1 Transcription Factor is Required to Maintain Pancreatic Beta Cell Mass. Mol Endocrinol, 20(8), 1853-66, 2006

Fujitani, Y., S. Fujitani, D. Boyer, M. Gannon, Y. Kawaguchi, M.K. Ray, M. Shiota, R.W. Stein, M.A. Magnuson, and C.V.E. Wright. Targeted deletion of cis-regulatory region for pdx1 reveals dosage responses of foregut differentiation, pancreas organogenesis, and function. Genes and Development, 20(2), 253-66, 2006.

Zhang, H, Fujitani, Y, Wright, CV, Gannon, M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis, 42(3), 210-7, 2005

Brissova, Marcela, Fowler, Michael, Wiebe, Peter, Shostak, Alena, Shiota, Masakazu, Radhika, Aramandla, Lin, P Charles, Gannon, Maureen, Powers, Alvin C. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes, 53(5), 1318-25, 2004

Frigeri, Claudia, Martin, Cyrus C, Svitek, Christina A, Oeser, James K, Hutton, John C, Gannon, Maureen, O''Brien, Richard M. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes, 53(7), 1754-64, 2004.

Brissova, Marcela, Shiota, Masakazu, Nicholson, Wendell E, Gannon, Maureen, Knobel, Susan M, Piston, David W, Wright, Christopher V E, Powers, Alvin C. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem, 277(13), 11225-32, 2002

Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J, Wright, Christopher V E. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet, 32(1), 128-34, 2002

Samaras, Susan E, Cissell, Michelle A, Gerrish, Kevin, Wright, Christopher V E, Gannon, Maureen, Stein, Roland. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol, 22(13), 4702-13, 2002

Zhang, Peichuan, McGrath, Barbara, Li, Sheng'ai, Frank, Ami, Zambito, Frank, Reinert, Jamie, Gannon, Maureen, Ma, Kun, McNaughton, Kelly, Cavener, Douglas R. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol, 22(11), 3864-74, 2002

Dutta, S, Gannon, M, Peers, B, Wright, C, Bonner-Weir, S, Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A, 98(3), 1065-70, 2001

Gannon, M, Gamer, L W, Wright, C V. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol, 238(1), 185-201, 2001

Gannon, M, Gilday, D, Rifkind, A B. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol Appl Pharmacol, 164(1), 24-37, 2000

Gannon, M, Herrera, P L, Wright, C V. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis, 26(2), 143-4, 2000

Gannon, M, Ray, M K, Van Zee, K, Rausa, F, Costa, R H, Wright, C V. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development, 127(13), 2883-95, 2000

Gannon, M, Shiota, C, Postic, C, Wright, C V, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000

Gerrish, K, Gannon, M, Shih, D, Henderson, E, Stoffel, M, Wright, C V, Stein, R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem, 275(5), 3485-92, 2000

Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999

Wu, K L, Gannon, M, Peshavaria, M, Offield, M F, Henderson, E, Ray, M, Marks, A, Gamer, L W, Wright, C V, Stein, R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol, 17(10), 6002-13, 1997

Gilday, D, Gannon, M, Yutzey, K, Bader, D, Rifkind, A B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem, 271(51), 33054-9, 1996

Gannon, M, Bader, D. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Development, 121(8), 2439-50, 1995

Yutzey, K, Gannon, M, Bader, D. Diversification of cardiomyogenic cell lineages in vitro. Dev Biol, 170(2), 531-41, 1995

Nakai, K, Ward, A M, Gannon, M, Rifkind, A B. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. J Biol Chem, 267(27), 19503-12, 1992

Wang, G, Higgins, P J, Gannon, M, Staiano-Coico, L. Transforming growth factor-beta 1 acts cooperatively with sodium n-butyrate to induce differentiation of normal human keratinocytes. Exp Cell Res, 198(1), 27-30, 1992

Rifkind, A B, Gannon, M, Gross, S S. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem Biophys Res Commun, 172(3), 1180-8, 1990



Book Chapters

Gannon, M., K. Gerrish, R. Stein and C.V.E. Wright. (2000). Role of pdx-1 in pancreatic development. Frontiers in Diabetes: Molecular pathogenesis of MODYs. F.M. Matschinsky and M.A. Magnuson, Eds. S. Karger AG. Basel, Switzerland. pp. 166-180.

Gannon, M. and C.V.E. Wright. (1999). Endoderm patterning and organogenesis. Cell Lineage and Fate Determination. Sally Moody, Ed. Academic Press. San Diego, CA. pp. 583-615.

Gannon, M, Bader, D. Avian cardiac progenitors: methods for isolation, culture, and analysis of differentiation. Methods Cell Biol, 52, 117-32, 1997

Maureen Gannon, Ph.D.

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism

Department of Molecular Physiology and Biophysics

Department of Cell and Developmental Biology

Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232

office: (615) 936-2676
lab: (615) 936-2683
fax: (615) 936-1667