SLO3 K Channel: A Novel Target for Contraception
09/13/2017 – 08/31/2018
Develop novel contraceptives targeting sperm-specific SLO3 potassium channels
Development of small-molecule mosquitocides for controlling the primary vector of Zika virus, Aedes aegypti
Develop mosquito insecticides targeting Kir channels
Drug discovery contract with Ono Pharmaceuticals
10/15 – 9/19
Development of novel modulators of potassium channels
Molecular pharmacology and physiology of kidney potassium transport
2R01DK082884-06 NIH/NIDDK (Competitive renewal)
12/10 - 11/15
Development of small-molecule Kir4.2 modulators for the treatment of type 2 diabetes
Vanderbilt Diabetes and Research Training Center Pilot & Feasibility Grant (PI)
3/1/2014 – 2/28/2016
The goal of this Pilot and Feasibility grant is to develop and implement a high-throughput screening assay for the putative type II diabetes target Kir4.2.
High-Throughput discovery of chemicals that induce kidney failure in the Malarial vector Anopheles gambiae
GRT00024873 (Denton-Site PI)
Foundation for the NIH/Bill and Melinda Gates Foundation
The goal of this project is to employ high-throughput screening and medicinal chemistry to develop novel insecticides targeting malaria-carrying mosquitoes.
Chemical probes of the astroglial potassium channel Kir4.1
5R21 NS073097-01S1 (PI)
The goal of this grant is to develop a high-throughput assay with which to screen for small-molecule modulators of the inward rectifying potassium channel Kir4.1.
Integrative membrane physiology in the post-genome era
R13 GM103172-01 (PI)
Conference grant to support the 66th Annual Meeting and Symposium of the Society of General Physiologists, for which I was an organizer.
Molecular and cellular mechanisms of Kir1.1 K+ channel dysfunction in antenatal Bartter syndrome
American Heart Association Southeast Affiliate Beginning Grant-In-Aid (PI)
High throughput discovery of novel modulators of ROMK K+ channel activity
R21 NS057041-01 (PI)
The goal of this project was to develop a high throughput-compatible assay of ROMK K+ channel function for high-throughput library screening.