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Adult Appointments
(615) 936-5321
Pediatric Appointments
(615) 343-2454

Administrative Office
Division of Hepatobiliary Surgery & Liver Transplantation, VUMC
801 Oxford House
1313 21st Ave. South,
Nashville, TN 37232-4753
Phone: (615) 936-0420

Dr. Seth KarpProfessor & Chair, Section of Surgical Sciences
Surgeon-in-Chief, Vanderbilt University Hospital
Director, Vanderbilt Transpant Center

H. William Scott Jr. Professor

Dr. Karp joined the Vanderbilt surgical faculty in 2011 as Director of the Vanderbilt Transplant Center. Over the next four years, the center provided patients outstanding outcomes and experienced a period of significant growth to become one the largest centers in the country.

In 2015, Dr. Karp was appointed Chair of the Department of Surgery and H. William Scott Professor. The Department consists of general surgery including bariatrics and colorectal, trauma and critical care including burns, transplantation, vascular surgery, and surgical oncology.

In 2018 Dr. Karp suceeded Dr. Beauchamp as Chair of the Section of Surgical Sciences, which consists of approximatley 18 surgical service departments and divisions at the medical center.

Dr. Karps clinical interests include liver transplantation in the adult and pediatric population, kidney and pancreas transplantation, and general surgery in patients with liver or kidney disease. Dr. Karp is active nationally in transplantation and has served in numerous leadership positions including chair of the organizing committee for the American Transplant Congress. He currently serves on the Liver-Intestine Committee of the United Network for Organ Sharing.

Dr. Karps clinical research interests include increasing the number of organs available for transplantation and optimizing the use of all organs to improve results. In addition, his lab is developing a test to diagnose gastrointestinal bleeding.

Dr. Karp maintains a funded basic research laboratory investigating the mechanisms of liver regeneration. His lab has identified molecules and mechanisms necessary for liver regeneration and an endogenous pathway that limits regeneration to preserve liver function.

Dr. Karp has lectured around the world on liver physiology and transplantation and serves on the editorial board of the American Journal of Transplantation and the Journal of Cellular and Molecular Gastroenterology and Hepatology. He has published numerous original manuscripts, reviews, book chapters, and a book.


  • 1988 A.B. Harvard College, Boston, MA
  • 1989 A.M. Harvard Graduate School of Arts and Sciences, Boston, MA
  • 1994 M.D. Harvard-Massachusetts Institute of Technology (M.I.T.)/Division of Health Sciences and Technology

Postdoctoral Training

  • 1994-1997 Resident, Surgery, Brigham and Womens Hospital, Boston, Mass.
  • 1997-1999 Postdoctoral Fellow, Harvard University, Cambridge, Mass.
  • 1999-2000 Resident, Surgery, Brigham and Womens Hospital, Boston
  • 2000-2001 Chief Resident, Surgery, Brigham and Womens Hospital, Boston
  • 2001-2003 Fellow in Transplantation, Johns Hopkins Hospital, Baltimore, Md.

Publications and Presentations

Dr. Karps research appears in such noted peer-reviewed journals as the American Journal of Transplantation and the Journal of Experimental Medicine. Review some of his published abstracts at PubMed.

Dr. Karp's CV is available in PDF format.
For appointments, referrals and consultations, Dr. Karp can be reached at:

Vanderbilt University Medical Center
Division of Kidney & Pancreas Transplantation
Division of Hepatobiliary Surgery & Liver Transplantation

D-4313 Medical Center North
Nashville, TN
(615) 343-2735