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Our Publications


Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities. Khan IS, Odom M, Ehtesham M, Colvin D, Quarles CC, McLaughlin B, Singer RJ (2015) J Neurosurg : 1-8 26544777

CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B (2015) Antioxid Redox Signal 23(6): 535-49 25602369

The Interview

BethAnn McLaughlin's 2014 JAMA interview on the future of science funding is right here.


BN Lizama Manibusan Redox Sensors as Regulators of Mitophagic Signaling: Novel Targets of Therapy for Ischemic Stroke Vanderbilt Reviews Neuroscience

Comment: McLaughlin, BA What Women Need to Succeed in Science The Scientist


Alcendor DJ, Block FE, Cliffel DE, Daniels J, Ellacott  KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B., McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP (2013) Neurovascular unit on a chip: Implications for translational applications. Stem Cell Res Ther. 2013;4 Suppl 1:S18


Lizama-Manibusan, B., and McLaughlin, B. A. (2013) Redox modification of proteins as essential mediators of CNS autophagy and mitophagy., FEBS Letters S0014-5793, 00452.

Grelli, K. N., Palubinsky, A. M., Kale, A. C., Lizama-Manibusan, B. N., Stankowski, J. N., Milne, G. L., Singer, R., and McLaughlin, B. (2013) Alteration of Isocitrate Dehydrogenase Following Acute Ischemic Injury as a Means to Improve Cellular Energetic Status in Neuroadaptation, CNS Neurol Disord Drug Targets [Epub ahead of print].

Gorrindo, P., Lane, C. J., Lee, E. B., McLaughlin, B., and Levitt, P. (2013) Enrichment of Elevated Plasma F2t-Isoprostane Levels in Individuals with Autism Who Are Stratified by Presence of Gastrointestinal Dysfunction, Plos One 8, e68444.

McLaughlin, B.A. and Gidday, J. Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protection in Patients Suffering from Stroke. Translational Stroke Research (Online) 


Figure from Lizama Manibusan FEBS Letters 2013 linking redox senstive BNIP to hypoxic signaling via the Krebs cycle



McKenzie, J. R., Palubinsky, A. M., Brown, J. E., McLaughlin, B. A., and Cliffel, D. E. (2012) Metabolic  Multianalyte Microphysiometry Reveals Extracellular Acidosis is an Essential Mediator of Neuronal Preconditioning, ACS Chemical Neuroscience.
Grelli, K. N., Palubinsky, A. M., Stankowski, J. N., Kale, A. C., Milne, G. L., and McLaughlin, B. A. (In Progress) Selective Alteration of Isocitrate Dehydrogenase Following Acute Ischemia as a Means to Improve Cellular Energetic Status  
Palubinsky, A. M., Martin, J. M., and McLaughlin, B. A. (2012) The Role of Central Nervous System Development in Late Onset Neurodegenerative Disorders, Developmental Neuroscience.
Albers, E. A., Donahue, B. S., Milne, G. L., Saville, B. R., Wang, W., Bichell, D., and McLaughlin, B. A. (2012 - In Press) Perioperative plasma F2-Isoprostane levels correlate with markers of impaired ventilation in infants with single ventricle physiology undergoing stage II surgical palliation on cardiopulmonary bypass., Pediatric Cardiology.
McLaughlin, B. A., Buendia, M. A., Saborido, T. P., Palubinsky, A. M., Stankowski, J., and Stanwood, G. D. (2012) Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments, Public Library of Science One.


Stankowski, J. N., Zeiger, S. L. H., Cohen, E. L., DeFranco, D. B., Cai, J., and McLaughlin, B. A. (2011) C-Terminus of HSC70 interacting protein increases following stroke and impairs survival against acute oxidative stress. Antioxidants and Redox Signaling 14, 1787-1801.

Stankowski, J. N., Condreanu, G. S., Liebler, D., and McLaughlin, B. A. (2011) Analysis of protein targets by oxidative stress using oxyblot and biotin-avidin capture methodology. in Neuromethods: Cell Culture Techniques (Aschner, M., Price, A., and Sunol, C., Eds.), Spring Science.
Brooks, J. D., Musiek, E. S., Koestner, T. R., Stankowski, J. N., Howard, J. R., Brunoldi, E. M., Porta, A., Zanoni, G., Vidari, G., Morrow, J. D., Milne, G. L., and McLaughlin, B. (2011) The fatty acid oxidation product 15-A3t-Isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation, Journal of Neurochemistry.

2010 and Previous Years

Zeiger, S. L. H., McKenzie, J. R., Stankowski, J. N., Martin, J. A., Cliffel, D. E., and McLaughlin, B. (2010) Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802, 1095-1104.
Kleman, A. M., Brown, J.E., Zeiger, S.L., Hettinger, J.C., Brooks, J.D., Holt, B., Morrow, J.D. Musiek, E.S., Milne, G., McLaughlin, B.A. (2010) p66shc’s role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone. Autophagy 6, 73-74.
Brown, J. E., Zeiger, S. L. H., Hettinger, J. C., Brooks, J. D., Holt, B., Morrow, J. D., Musiek, E. S., Milne, G., and McLaughlin, B. (2010) Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning, Journal of Neuroscience 30, 5242-5252.
Albers, E., Bichell, D., and McLaughlin, B. A. (2010) New Approaches to Neuroprotection in Infant Heart Surgery, Pediatric Research 68, 1-9 
Stanwood, GD, Leitch, DB, Savchenko, V, Wu, J, Fitsanakis, VA, Anderson, DJ, Stankowski, JN, Aschner, M, McLaughlin, B.A. Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem, 110(1), 378-89, 2009.

Zeiger, SL, Musiek, ES, Zanoni, G, Vidari, G, Morrow, JD, Milne, GJ, McLaughlin, B.A. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Free Radic Biol Med, 2009.


Musiek, ES, Brooks, JD, Joo, M, Brunoldi, E, Porta, A, Zanoni, G, Vidari, G, Blackwell, TS, Montine, TJ, Milne, GL, McLaughlin, B.A., Morrow, JD. Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the {omega}-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid. J Biol Chem, 283(29), 19927-35, 2008.

Kirshner, H. and McLaughlin, B.A. (2008) Wagging the dog- Moving closer to features defined by basic scientists, the protection of prodromal transient ischemic attacks reveals itself.  European Journal of Neurology.  In press 


Altay, T, McLaughlin, B.A., Wu, J.Y., Park, T.S. and Gidday, J. (2007) Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia.  Experimental Neurology  207 186–194. 

O’Duffy, A.E., Bordelon, Y.M. and McLaughlin, B.A. (2007) Killer proteases and little strokes—how the things that do not kill you make you stronger.  Journal of Cerebral Blood Flow and Metabolism  1-14. 

Musiek, E.M, McLaughlin B.A., and Morrow J.D. (2007) Electrophilic cyclopentenone isoprostanes in neurodegeneration. Journal of Molecular Neuroscience 33:80–86


Milne, G. L., Musiek, E. S., Zanoni, G., Vidari, G., McLaughlin, B., Morrow, J. D.(2006) Development of a novel liquid chromatography-mass spectrometric assay to measure formation of highly reactive cyclopentenone isoprostanes in vivo Clinical Pharmacology & Therapeutics 79, 36. 

Musiek, E.M., Breeding, R.A., Milne G., Morrow, J. and McLaughlin B.A. (2006) Cyclopentenone Isoprostanes Are Novel Bioactive Products Of Lipid Oxidation Which Enhance Neurodegeneration.  Journal of Neurochemistry 97, 1301-1313  


Musiek, E., Milne, G. I., McLaughlin, B. A. & Morrow, J.D. (2005). Cyclopentenone eicosanoids as mediators of neurodegeneration: A pathogenic mechanism of oxidative stress and cyclooxyanese-mediated neurotoxicity. Brain Pathology 15: 149-158.

Milne, G. L., Musiek, E. S., Zanoni, G., Vidari, G., McLaughlin, B., Morrow, J. D. (2005) Development of a high performance liquid chromatography-electrospray ionization tandem mass spectrometric (LC/ESI/MS/MS) assay to quantify highly reactive cyclopentenone eicosanoids in vivo. Free Radical Biology and Medicine 39, 113. 

DiNapoli, M. & McLaughlin B. A. (2005). Role of the ubiquitin proteasome pathway in stroke and transient ischemic attacks - therapeutic opportunities for providing neuroprotection. Current Opinions in Investigational Drugs. 6, 686-699.  


McLaughlin, B. A. (2004). The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis, 9, 111-121.  


McLaughlin, B. A., Erhardt, J. A., Legos, J. J., White, R., Barone, F. C., Parsons, A. A., & Aizenman, E. (2003). Caspase activation is required for neuroprotection in ischemic preconditioning. Proceedings in the National Academy of Sciences USA, 100, 715-720. 


Du, S., McLaughlin, B. A., Pal, S., & Aizenman, E. (2002). In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and mitogen-activated protein kinase-dependent pathway. Journal of Neuroscience, 22, 7408-7416.

Legos, J. J., McLaughlin, B. A., Skaper, S. D., Strijbos, P. J. M. L., Herin, G. A., Parsons, A. A., Aizenman, E., Barone, F. C., & Erhardt, J. A. (2002). The selective p38 MAP kinase inhibitor SB239063 protects rat hippocampal and primary cortical neurons from excitotoxic death. European Journal of Pharmacology 447, 37‑42. 

Leszkiewicz, D. N., McLaughlin, B. A., & Aizenman, E. (2002). Protein kinases and light: Unlikely partners in a receptor localization puzzle. Physiology & Behavior, 77, 533-536. 


McLaughlin, B. A., Pal, S., Tran, M. P., Parsons, A. A., Barone, F., Erhardt, J. A., & Aizenman, E. (2001). p38 activation is required upstream of potassium current enhancement and caspase cleavage in oxidant-induced neuronal apoptosis. Journal of Neuroscience, 21, 3303-3311.

Nutall, M. E., Lee D., McLaughlin B. A., Erhardt J. A. (2001) Selective inhibitors of apoptotic caspases: Implications for novel therapeutic approaches. Drug Discovery Today, 6, 85-91. 

McLaughlin, B.A. (2001). Dopamine neurotoxicity and neurodegeneration. In M. F. Chesselet (Ed.), Molecular mechanisms of cell death, pp. 195-231.  Towowa, NJ: Humana Press. 


Aizenman, E., Stout, A. K., Hartnett, K. A., Dineley, K. E., McLaughlin, B. A., & Reynolds, I. J. (2000). Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release. Journal of Neurochemistry, 75 (5), 1878-1888. 

Hoyt, K. R., McLaughlin, B.A., Higgins, D. S., Jr., & Reynolds, I. J. (2000). Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. Journal of Pharmacology and Experimental Therapeutics, 293(2), 480-486. 

Pre 1999

McLaughlin, B. A., & Levitt, P. (1999). Molecular basis of neurological disease. In M. T. T. Wong-Riley (Ed.), Neuroscience secrets, pp. 349-356.  Philadelphia: Hanley & Belfus, Inc.

McLaughlin, B. A., Nelson, D., Erecinska, M., & Chesselet, M. F. (1998). Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor. Journal of Neurochemistry, 70(6), 2406-2415. 

McLaughlin, B. A., Nelson, D., Silver, I. A., Erecinska, M., & Chesselet, M. F. (1998). Methylmalonate toxicity in primary neuronal cultures. Neuroscience, 86(1), 279-290.

McLaughlin, B. A., Spencer, C., & Eberwine, J. (1996). CAG trinucleotide repeats interact with RNA binding proteins. American Journal of Human Genetics, 59(3), 561-569. 

Robinson, M. B., Hopkins, K., Batshaw, M. L., McLaughlin, B. A., Heyes, M. P., & Oster-Granite, M. L. (1995). Evidence for excitoxicity in the brain of the ornithine carbamoyltransferase deficent sparse for mouse. Developmental Brain Research, 90(1-2), 35-44. 

Eberwine, J. W., & McLaughlin, B. A. (1995). Striatal RNA-binding proteins interact with huntingtin mRNA. In M. A. Ariano & D. J. Surmeier (Eds.), Molecular and cellular mechanisms of neostriatal function, pp. 143-149. 

Batshaw, M. L., Yudkoff, M., McLaughlin, B. A., Gorry, E., Anegawa, N. J. Smith, L. A. S., Hyman, S. L., & Robinson, M. B. (1995). The sparse fur mouse as a model for gene therapy in ornithine carbamoyltransferase deficiency. Gene Therapy, 2, 1-7. 

           Depolarized: verb, used with object. 1) To cause a reassembly of sharply divided in factions. 2) The new Vanderbilt Brain Institute Blog.

2016 and 2017

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. 
Cell Death Differ. 2017 

Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.

Lizama BN, Palubinsky AM, McLaughlin B.  Neurochem Int. 2017 

Dynamic phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in response to oxidative and electrophilic stress.

    Morales Betanzos C, Federspiel JD, Palubinsky AM, McLaughlin B, Liebler DC. Chem Res Toxicol. 2016 

Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures.

    Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B. ACS Chem Neurosci. 2016 

Small vessel disease captured using MRI.

Silent Cerebral Small Vessel Disease in Restless Legs Syndrome.

    Ferri R, Cosentino FI, Moussouttas M, Lanuzza B, Aricò D, Bagai K, Wang L, McLaughlin BA., Walters, AS. Sleep. 2016 

Assembly dynamics and stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) signalosome in response to electrophile stress.

    Federspiel JD, Codreanu SG, Palubinsky AM, Winland AJ, Betanzos CM, McLaughlin B, Liebler DC  Mol Cell Proteomics. 2016 

Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities.

    Khan IS, Odom M, Ehtesham M, Colvin D, Quarles CC, McLaughlin B, Singer RJ. J Neurosurg. 2016 

Rat Model: MMP9 Staining Around Vessels 7d Post Stroke

Silent Cerebral Small Vessel Disease in Restless Legs Syndrome. Ferri R, Cosentino FI, Moussouttas M, Lanuzza B, Aricò D, Bagai K, Wang L, McLaughlin B, Walters AS (2016) Sleep 27091527

Assembly dynamics and stoichiometry of the apoptosis signal-regulating kinase (ASK) signalosome in response to electrophile stress. Federspiel JD, Codreanu SG, Palubinsky AM, Winland AJ, Morales Betanzos C, McLaughlin B, Liebler DC (2016) Mol Cell Proteomics 27006476

the scientist

See Dr. McLaughlin's comment to Women in Science 2/2014

Our paper "CHIP is an Essential Determinant of Mitochondrial Stress Signaling" is online now!  GET IT HERE.  Press release here.

Vanderbilt voted one of The Top 10 Places to Do a Post Doctoral Fellowship.  Find out more here

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Brain on a Chip Funded!

The McLaughlin lab joins Vanderbilt colleagues in creating a one of a kind biofluidics platform for drug discovery.  Find out more here