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Neurology Chair


Dane Chetkovich, M.D., Ph.D., Professor and Chairman
of Neurology

Faculty By Divisions


Dane M. Chetkovich, M.D., Ph.D.

BIOGRAPHICAL SUMMARY

Dr. Chetkovich earned a B.A. in Biochemistry and B.S. in Zoology in 1988 from the University of Texas at Austin. He attended Baylor College of Medicine in Houston, Texas, where he earned a Ph.D. in Neuroscience in 1992 and M.D. in 1994.  He completed an internship at Baylor followed by residency at University of California, San Francisco where he served as chief resident in neurology in Neurology and completed a postdoctoral fellowship in 2002.  He joined Vanderbilt in September 2017 after being at Northwestern University Feinberg School of Medicine in Chicago for fifteen years where he was professor of Neurology and Physiology and director of the Medical Scientist Training Program.

Dr. Chetkovich has been the recipient of numerous awards and honors, including the Derek Denny-Brown Young Neurological Scholar Award by the American Neurological Association in 2010. He has also received several teaching awards including the John A. Kessler Teaching Award in 2016 and Neurology Resident Teaching Award in 2015.

Dr. Chetkovich is a frequently invited speaker at universities and meetings around the country and around the world. He has served on numerous review boards and committees, has participated in a number of study sections and is a member of the American Board of Psychiatry and Neurology committee responsible for writing the certification exam that is required for neurologists to become board-certified in the United States.

Dr. Chetkovich is a general neurologist who is licensed to practice medicine in Tennessee, and he has been a member of the American Board of Psychiatry and Neurology since 2000.

RESEARCH SUMMARY

Dr. Chetkovich’s research laboratory is focused on the molecular mechanisms that underlie the targeting of ion channels to synapses and other specialized areas of neurons.  In particular, Dr. Chetkovich’s laboratory a multi-faceted approach, including electrophysiological, biochemical, molecular biology tools and gene therapy regulation of voltage-gated ion channels and how regulation of these channels may play a role in neuropsychiatric diseases such as epilepsy, autism and major depressive disorder. 

SELECTED RECENT PUBLICATIONS

Chan, C. S., Glajch, K. E., Gertler, T. S., Guzman, J. N., Mercer, J. N., Lewis, A. S., Goldberg, A. B., Tkatch, T., Shigemoto, R., Fleming, S. M., Chetkovich, D. M., Osten, P., Kita, H. and Surmeier, D. J. (2011). "HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease." Nat Neurosci 14(1): 85-92, PMCID: 3058391.
Han, Y., Noam, Y., Lewis, A. S., Gallagher, J. J., Wadman, W. J., Baram, T. Z. and Chetkovich, D. M. (2011). "Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites." J Biol Chem 286(23): 20823-34, PMCID: 3121500.
Lewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., Chen, X., Bender, R. A., Estep, C. M., Popov, A. B., Kang, C. E., Van Veldhoven, P. P., Bayliss, D. A., Nicholson, D. A., Powell, C. M., Johnston, D. and Chetkovich, D. M. (2011). "Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice." J Neurosci 31(20): 7424-40, PMCID: 3169171.
Bankston, J. R., Camp, S. S., DiMaio, F., Lewis, A. S., Chetkovich, D. M. and Zagotta, W. N. (2012). "Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels." Proc Natl Acad Sci U S A 109(20): 7899-904, PMCID: 3356637.
Khurana, S., Liu, Z., Lewis, A. S., Rosa, K., Chetkovich, D. and Golding, N. L. (2012). "An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision." J Neurosci 32(8): 2814-23, PMCID: 3342760.
Huang, Z., Lujan, R., Martinez-Hernandez, J., Lewis, A. S., Chetkovich, D. M. and Shah, M. M. (2012). "TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels." J Neurosci 32(42): 14835-48, PMCID: PMCID in Process.
Han, Y., Lyman, K., Clutter, M., Schiltz, G. E., Ismail, Q. A., Prados, D. B., Luan, C. H. and Chetkovich, D. M. (2015). "Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels." J Biomol Screen 20(9): 1124-31, PMCID: PMC4755285.
Heuermann, R. J., Jaramillo, T. C., Ying, S. W., Suter, B. A., Lyman, K. A., Han, Y., Lewis, A. S., Hampton, T. G., Shepherd, G. M., Goldstein, P. A. and Chetkovich, D. M. (2016). "Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy." Neurobiol Dis 85: 81-92, PMCID: PMC4688217.
Han, Y., Heuermann, R. J., Lyman, K. A., Fisher, D., Ismail, Q. A. and Chetkovich, D. M. (2017). "HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects." Mol Psychiatry 22(3): 458-465, PMCID: PMC5233690.
Chen, H., Judkins, J., Thomas, C., Wu, M., Khoury, L., Benjamin, C. G., Pacione, D., Golfinos, J. G., Kumthekar, P., Ghamsari, F., Chen, L., Lein, P., Chetkovich, D. M., Snuderl, M. and Horbinski, C. (2017). "Mutant IDH1 and seizures in patients with glioma." Neurology 88(19): 1805-1813, PMCID: PMC5419985.