In order to successfully infect the different tissues and hosts they encounter, viruses must be able to efficiently bind, enter, and replicate in target cells and rapidly adapt to changing environmental pressures. Research in the Ogden lab is focused on the tropism and diversity mechanisms of segmented, dsRNA viruses in the Reoviridae family, including rotavirus and reovirus. Rotavirus is an important cause of diarrheal disease that results in the deaths of hundreds of thousands of infants and young children worldwide each year. Reovirus is an oncolytic in clinical trials for treatment of gliomas and other cancers. A main theme currently being explored in our laboratory is elucidation of packaging-mediated diversity mechanisms, including the frequency and dynamics of genome segment reassortment during co-infection and effects of altered RNA segments and genomeless particles on viral replication and population diversity. We also study virus-cell interactions that mediate viral attachment and entry and evolving antigenic properties of pathogenic rotaviruses. A long-term goal of the lab is to engineer dsRNA viruses to make better vaccines, therapeutics, and research tools.