Venkataraman Amarnath, Ph.D.



Research Associate Professor

Dept. of Pathology, Microbiology and Immunology


 Contact Information



Office Location:

MCN CC-3304

Phone: 615-343-5842



Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321 (2561)


US Mailing Address
School of Medicine

Dept. of Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321

Nashville , TN 37232-2561


  Disease Interests



Alzheimer’s, Diabetes



 Research Specialty


 Synthetic Organic Chemistry, Neurotoxicity Testing






Amarnath V, Amarnath K, Valentine WM.  2007.  Mechanism of decomposition of N,N-dialkyl dithiocarbamates.  Curr Topics Toxicol  4: 39-44. 


Boyden PA, Davies SS, Viswanathan PC, Amarnath V, Balser JR, Roberts LJ.  2007.  Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias.  J Cardiovas Pharmacol 50: 480-486. 


Davies SS, Amarnath V, Brame CJ, Boutaud O, Roberts LJ.  2007.  Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin g-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry.  Nature Protocols 2: 2079-2091. 


Valentine HL, Amarnath K, Amarnath V, Li W, Ding X, Valentine WM, Ichihara G.  2007.  Globin S-propylcysteine and urinary N-acetyl-S-propylcysteine as internal biomarkers of 1-bromopropane exposure.  Toxicolog Sci 98: 427-435. 


Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Roberts LJ.  2006.  Pyridoxamine analogues scavenge lipid-derived -ketoaldehydes and protect against H2O2-mediated cytotoxicity.  Biochemistry 45: 15756-15767.


Valentine HL, Amarnath K, Amarnath V, Valentine WM.  2006.  Dietary copper enhances the peripheral myelinopathy produced by oral pyrrolidine dithiocarbamate.  Toxicol Sci  89: 485-494. 


Fukuda K, Davies SS, Nakajima T, Ong B-H, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Jackson LJ, Balser JR. 2005.  Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.  Circulation Res  97: 1262-1269. 


Zagol-Ikapitte I, Masterson, TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA.  2005.  Prostaglandin H2-derived adducts of proteins correlate with Alzheimer’s disease severity.  J Neurochem 94: 1140-1145.


Aberle NS, Picklo MJ, Amarnath V, Ren J.  2004.  Inhibition of cardiac myocyte contraction by 4-hydroxy-2-nonenal.  Cardiovas Toxicol 4: 21-28. 


Meyer MJ, Mosely DE, Amarnath V, Picklo MJ.  2004.  Metabolism of 4-hydroxy-2-nonenal by central nervous system mitochondria is dependent on age and NAD+ availability.  Chem Res Toxicol 17: 1272-1279.