Mildred T. Stahlman, M.D.




Dept of Pediatrics

Dept of Pathology, Microbiology and Immunology



  Contact Information



Vanderbilt University School of Medicine

1125 MRB IV/Light Hall

Nashville, TN 37232-0656

Phone: 615-343-0443

Fax: 615-343-6182




  Research Specialty


 Neonatal pulmonary development outcome and pathology



  Disease Interests



Hyaline Membrane Disease

Prematurity, perinatal outcome



  Research Specialty



Lung development



  Research Description



Immunohistology and electron microscopy of  immature  lungs of mice and humans



  Clinical Interests



Perinatal outcome



  Other interests



Effects of poverty and social ills on perinatal disease and deaths



  Selected Publications



Stahlman MT, Gray ME: Immunogold EM localization of neurochemicals in human pulmonary neuroendocrine cells.  Microsc Res and Tech  37:77-91, 1997.


Stahlman MT, Gray ME, Whitsett JA:  Temporal-spatial distribution of hepatocyte nuclear factor-3b in developing human lung and other foregut derivatives.  J Histochem Cytochem 46:955, 1998.


Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF, Wert SE, Stahlman MT, Jobe AH, Ikegami M, Whitsett JA, Fisher JH:  Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.   J Biol Chem  273:28438-28443, 1998.


Khoor A, Whitsett JA, Stahlman MT, Olson SJ, Cagle PT:  Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.   Human Pathology 30:695-700, 1999.


Stahlman MT, Gray MP, Falconieri MW, Whitsett JA, Weaver TE:  Lamellar body formation in normal and surfactant protein B-deficient fetal mice.  Laboratory Investigation 80:395, 2000.


Zeng X, Gray M, Stahlman M, Whitsett JA:  TGF-$1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.  Dev Dyn 221:289-301, 2001.


Clark JC, Tichelear JW, Wert SE, Itoh N, Perl AKT, Stahlman MT, Whitsett JA:  FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.   Am J Physiol Lung Cell Mol Physiol  280:L705-L715, 2001.


Stahlman MT, Gray ME, Hull WM, Whitsett JA:  Immunolocalization of surfactant

Protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem 50:651-660, 2002.


Whitsett JA, Clark JC, Picard L, Tichelaar JW, Wert SE, Itoh N, Perl AKT, Stahlman MT:  Fibroblast growth factor 18 influences proximal programming during lung morphogenesis.  J Biol Chem 277:22743-22749, 2002.


Thomas AQ, Lane K, Phillips III J, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE:  Heterozygosity foe a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165:1322-1328, 2002.


Weaver TE, Na C-L, Stahlman M: Biogenesis of lamellar bodies and lysosomal organelles involved in storage and secretion of pulmonary surfactant. Cell Devel Biol 319:1-8, 2002.


Glasser SW, Detmer EA, Ikegami M, Na C-L, Stahlman MT, Whitsett JA: Interstitial pneumonitis in SP-C gene targeted mice. J Biolog Chemis 278:14291-14298, 2003.


Glasser SW, Detmer EA, Ikegami M, Na C-L, Stahlman MT, Whitsett JA:  Pneumonitis and emphysema in sp-C gene targeted mice.  J Biol Chem: 278:14291-14298; 2003.


Noah TL, Murphy PC, Alink JJ, Leigh MW, Hull WM, Stahlman MT, Whitsett JA: Bronchoalvelar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis.  Am J Respir Crit Care Med 168:685-691; 2003


Liu C, Ikegami M, Stahlman MT, Dey CR, Whitsett JA: Inhibition of alveolarization and altered pulmonary mechanics in mice expressing Gata-6.  Am J Physiol Lung Cell Mol Physiol 285:L1246-1254; 2003


Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson P, Rothenberg, Whitsett JA: Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131:953-964, 2004.


Khoor A, Stahlman MT, Johnson JM, Olson SJ, Whitsett JA.  Forkhead hox A2 transcription factor is expressed in all types of neuroendocrine lung tumors.  Hum Pathol 35:560-564; 2004.


Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, Whitsett JA.  Foxa2 is required for transition to air breathing at birth.  Proc Natl Acad Sci USA  101(40):14449-54, 2004.


Wan, Huajing, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA.  Compensatory roles of Fox a1 and Fox a2 during lung morphogenesis.  J Biol Chemis 280:13809-13816, 2005.


Ikegami M, LeCras TD, Hardie WD, Stahlman MT, Whitsett JA, Korfhagen TR.  TGF-a perturbs surfactant homeostasis in vivo. Am J Lung Cell Mol Physiol 289(1)L34-43,2005. Epub 2005 Mar 11.


Mucenski ML, Nation JM, Thitoff AR, Besnard V, Xu Y, Wert SE, Harada N, Taketo MM, Stahlman MT, Whitsett JA. Beta-catenin relates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289(6): L971-9, 2005. Epub 2005 Jul 22.


Altiok O, Yasumatsu R, Bingol-Karakoc G, Riese RJ, Stahlman MT, Dwyer W, Pierce RA, Bromme D, Weber E, Cataltepe S.  Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia.  Am J Respir Crit Care Med 173(3):318-26, 2006. Epub 2005  Sep 15.


Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, Torday JS. Evidence for the presence of lipofibroblasts in human lung. Exp Lung Res  32:379-393, 2006.


Stahlman MT, Besnard V, Wert SE, Weaver TE, Dingle S, XU Y, von Zychlin K, Olson SJ, Whitsett JA. Expression of ABCA3 in developing lung and other tissues. J Histochem Cytochem  55(1):71-83, 2007.


Metzger DE, Stahlman MT, Shannon JM. Misexpression of ELF5 disrupts lung branching  and inhibits epithelial differentiation. Dev Biol 320 (2008) 149-160.


Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett, JA. Deletion of SCAP in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Rold for Pulmonary Lipofibroblasts. Submitted for publication to the Journal of Biological Chemistry.


Sutherland MR, Gubhaju L, Stahlman MT, Black MJ. The Effects of Postnatal Retinoic Acid Administration on Nepron Endowment in the Preterm Baboon Kidney. Submitted for publication to Pediatric Research.