Host-Pathogen Interactions Division

Publications, Funding Announcements & Awards

 Kirsten R. Guckes, Graduate Student, Maria Hadjifrangiskou Lab

“Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor”
Kirsten R. Guckes, Maria Kostakioti, Erin J. Breland, Alice P. Gu, Carrie L. Shaffer, Charles R. Martinez III, Scott J. Hultgren, and Maria Hadjifrangiskou
PNAS September 23, 2013, doi: 10.1073/pnas.1315320110
Posted 9-26-13

Caroline Lai, Ph.D. , Former graduate student

Directional release of reovirus from the apical surface of polarized endothelial cells.
Lai CM, Mainou BA, Kim KS, Dermody TS.
MBio. 2013 Apr 9;4(2):e00049-13. doi: 10.1128/mBio.00049-13
Posted 9/25/13

Julia Bohannon, Postdoc, Edward Sherwood Lab

The Immunobiology of TLR4 Agonists: From Endotoxin Tolerance to Immunoadjuvants.
Bohannon JK, Hernandez A, Enkhbaatar P, Adams WL, Sherwood ER.
Shock. 2013 Aug 28. [Epub ahead of print] PMID: 23989337
Posted 9/25/13

Edward Sherwood, Professor

Competitive renewal funded 7/1/2013

New grant funded 6/1/2013
Posted 9/25/13

Indriati Hood Ph.D., fourth year medical student, Eric Skaar Lab

Loss of mitochondrial protein FUS1 augments host resistance to Acinetobacter baumannii infection.
Hood MI, Uzhachenko R, Boyd K, Skaar EP, Ivanova A.
Infect Immun. 2013 Sep 16. [Epub ahead of print] PMID: 24042119
Posted 9-24-13

Allison Farrand Ph.D., Postdoc, Eric Skaar Lab

Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.
Farrand AJ, Reniere ML, Ingmer H, Frees D, Skaar EP.
J Bacteriol. 2013 Aug 30. [Epub ahead of print] PMID: 23995637
Posted 9-24-13

Neal Hammer Ph.D., Postdoc, Eric Skaar Lab

Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host.
Hammer ND, Reniere ML, Cassat JE, Zhang Y, Hirsch AO, Indriati Hood M, Skaar EP.
MBio. 2013 Jul 30;4(4). doi:pii: e00241-13. 10.1128/mBio.00241-13. PMID: 23900169
Posted 9-24-13

Ahmed Attia Ph.D., former Postdoc, Eric Skaar Lab

Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host-pathogen interface.
Attia AS, Cassat JE, Aranmolate SO, Zimmerman LJ, Boyd KL, Skaar EP.
Pathog Dis. 2013 Jul 11. doi: 10.1111/2049-632X.12063. [Epub ahead of print] PMID: 23847107
Posted 9-24-13

Thomas Kehl-Fie Ph.D., Postdoc, Eric Skaar Lab

MntABC and MntH Contribute to Systemic Staphylococcus aureus Infection by Competing with Calprotectin for Nutrient Manganese.
Kehl-Fie TE, Zhang Y, Moore JL, Farrand AJ, Hood MI, Rathi S, Chazin WJ, Caprioli RM, Skaar EP.
Infect Immun. 2013 Sep;81(9):3395-405. doi: 10.1128/IAI.00420-13. Epub 2013 Jul 1. PMID: 23817615
Posted 9-24-13

Jens Krause, former postdoc, James Crowe Lab.

Antibody Recognition of the Pandemic H1N1 Influenza Hemagglutinin Receptor Binding Site.
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE Jr, Ward AB, Wilson IA.
J Virol. 2013 Sep 11. [Epub ahead of print] PMID: 2402732
Posted 9-23-13

Natalie Thornburg, staff scientist, James Crowe Lab.

Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE Jr.
J Clin Invest. 2013 Sep 3. doi:pii: 69377. 10.1172/JCI69377. [Epub ahead of print] PMID: 23999429
Posted 9-23-13

Danyvid Olivares-Villagomez, Research Assistant Professor, Van Kaer lab

In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ.
Van Kaer L, Rabacal WA, Scott Algood HM, Parekh VV, Olivares-Villagómez D.
PLoS One. 2013 Jul 3;8(7):e67821. doi: 10.1371/journal.pone.0067821. Print 2013.
Posted 9-23-13.

Bernardo Mainou, Ph.D. (Research Instructor in Pediatrics)

Reovirus cell entry requires functional microtubules.
Mainou BA, Zamora PF, Ashbrook AW, Dorset DC, Kim KS, Dermody TS.
MBio. 2013 Jul 2;4(4). doi:pii: e00405-13. 10.1128/mBio.00405-13.
Posted 9-23-13.

Seth Bordenstein, Associate Professor

Mom knows best: The universality of maternal microbial transmission.
Funkhouser, L.J. and S.R. Bordenstein (2013)
PLOS Biology (11)8: e1001631.

•  Featured in New York Times column by Carl Zimmer
•  PLOS Biologue post by Jonathan Eisen

The hologenomic basis of speciation: Gut bacteria cause hybrid mortality in the genus Nasonia.
Brucker, R.M. and S.R. Bordenstein (2013)
Science. 341(6146): 667-669

•  Featured in Nature News and Comment, Nature News and Views, Vanderbilt Research News, Science Now, Futurity, io9, Newswise, GenomeWeb, Headlines and Global News, PlanetSave,, Pacific Standard, Science360, Science World Report, New Scientist, Science News, Medical News Today, etc.

•  Radio: Public Radio International's  "Living on Earth" and Pacifica Radio Houston
Posted 9-23-13.

Vrajesh Parekh, Research Assistant Professor

Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells

Keith T. Wilson and Luc Van Kaer, Vrajesh V. Parekh, Lan Wu, Danyvid Olivares-Villagómez.J Immunol 2013; 190:1948-1960; Prepublished online 23, January 2013; doi: 10.4049/jimmunol.1201718

Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34

Vrajesh V. Parekh, Lan Wu, Kelli L. Boyd, Janice A. Williams, Jennifer A. Gaddy, Danyvid Olivares-Villagómez, Timothy L. Cover, Wei-Xing Zong, Jianhua Zhang and Luc Van Kaer.
J Immunol
2013; 190:5086-5101; Prepublished online 17, April 2013; doi: 10.4049/jimmunol.1202071
Posted 9-23-13.